The Consequences and Causes of Premature Progesterone Rises during Ovarian Stimulation
Professor Julian Jenkins, D.M, F.R.C.O.G.
Senior Director, Global Medical Affairs, Ferring International Center SA, Switzerland
Controversy exists whether there is any adverse influence of elevated serum progesterone levels during the late follicular phase of ovarian stimulation prior to ART: a meta-analysis by Venetis (2007) of 700 patients found an increase in progesterone concentrations did not increase pregnancy rates while a single centre study in 4,032 patients found a highly significant negative correlation between ongoing pregnancy rates and serum progesterone levels.
According to the ‘two-cell, two-gonadotrophin’ hypothesis, it would be anticipated that an ovary, with a large number of growing follicles stimulated by high FSH concentrations, will produce and secrete more progesterone than a single follicle in the normal mid-follicular phase when FSH concentrations are declining. Further, it would predict that gonadotrophins that contain LH activity may help offset the rise in progesterone levels associated with multiple follicle growth. This lecture will review the evidence.
Date: Tuesday 12 October 2010
Time: 7.00am to 8.15am
Venue: Meeting Rooms 1&2, Adelaide Convention Centre
Information regarding registration for the breakfast will be available shortly.